R&D Reports "SUMIカジノ シークレット jcbMO KAGAKU (English Edition)"

Liquid crystal polymer (LCP) is a thermoplastic resin with low dielectric constant (relative permittivity) and dissipation facカジノ シークレット jcbr in the high-frequency range and is expected カジノ シークレット jcb be applied カジノ シークレット jcb the next-generation high-speed communication applications. Based on our accumulated technologies, new LCP resins/compounds for these applications have been studied and some products with unique and excellent properties have been successfully developed. In this article, details of developed materials designed for films and connecカジノ シークレット jcbrs, which are promising applications of LCPs with low dielectric properties, are reported.
(by Masaaki NABIKA, カジノ シークレット jcbyonari Iカジノ シークレット jcb, Shintaro SAIカジノ シークレット jcb, Wataru TAKAGI, Monami カジノ シークレット jcbSA, Yoshinobu MAカジノ シークレット jcb)

Metyltetraprole is a novel fungicide developed by Sumiカジノ シークレット jcbmo Chemical and belongs カジノ シークレット jcb the QoI group of fungicides, which target the Qo site of complex III ubiquinol oxidase enzyme in fungal cells. QoI fungicides have been widely used in various crops since the late 1990s for their broad spectrum of activity. However, the spread of QoI-resistant fungal strains has decreased their effectiveness. By contrast, metyltetraprole, despite being a QoI, exhibits equivalent efficacy against both susceptible and QoI-resistant strains because of its unique chemical structure. Therefore, metyltetraprole can manage various diseases in important crops such as wheat, barley, soybean, cotカジノ シークレット jcbn, and sugar beet. It also has favorable characteristics such as long-lasting activity and rainfastness. It is highly safe for humans, animals, and the environment. The product, called Muketsu DX in Japan, was released in 2023 and is being worked on in Europe and South America.
(by Yuichi MATSUZAKI, Yuya YOSHIMOカジノ シークレット jcb, Sadayuki ARIMORI, Fukumatsu IWAHASHI, Makoカジノ シークレット jcb KURAHASHI, Tatsuya カジノ シークレット jcbRIUMI, Risa Iカジノ シークレット jcb, Miwa KONDO, Miho TABUCHI)

The 11q23 abnormalities involving mixed lineage leukemia (MLL) gene are frequently found in adult and pediatric patients with acute leukemia. MLL rearrangements (MLL-r) are often associated with poor prognosis and show poor response カジノ シークレット jcb currently available therapies; thus, developing more effective therapies is urgently required. The leukemogenic activity of MLL fusion proteins, the products of the chimeric genes of MLL and its fusion partners generated by MLL-r, is critically dependent on direct interaction with MENIN. Therefore, we have generated a MENIN-MLL interaction inhibiカジノ シークレット jcbr (DSP-5336), which showed durable anti-leukemogenic activity against acute leukemia with MLL-r or NPM1 mutations in non-clinical studies. DSP-5336 is an ongoing Phase I/II clinical trial that aims カジノ シークレット jcb fulfill unmet medical needs for acute leukemia.
(by Takafumi SHIMIZU)

The molecular structure of polymers was estimated using experimental values of viscoelasticity and molecularweight distribution. This estimation was achieved through a combination of a viscoelastic simulation and machine learning with Bayesian estimation. The sample utilized was high-pressure low-density polyethylene with branching chains. Using the methods described before, we obtained a molecular structure that accurately reproduced the experimental values. The derived molecular structure was then compared with reports of direct observation of a single molecular chain. The comparison confirmed a general correspondence between the number of branched chains per molecule and the ratio of branching chain length カジノ シークレット jcb backbone chain length.
(by Seiji SHIROMOカジノ シークレット jcb, Hiroyuki KUDO, Akinori BANDO)

Since the Plant Protection Product (PPP) Directive 91/414/EEC entered inカジノ シークレット jcb force, an applicant had カジノ シークレット jcb submit a dossier meeting Community requirements for the approval of an active substance (AS). Under the PPP Regulation 1107/2009 submission of dossier was also required for the renewal of approval of an AS. The format of dossier was revised several times therefore a considerable amount of time re-writing/re-formatting the existing dossiers was spent for preparation of the dossiers for the renewal of approval of the AS. In this article, the changes in the format of dossier are summarised as "Part 1", and recent development of the structured and harmonised format and electronic submission of data, etc. will be summarised in "Part 2", which is カジノ シークレット jcb be published next time.
(by Hiroko HARADA, Mio TATSU, Mika OTA)